Microfluidic Flow Assay for Measuring Hemostatic Phenotypes
Ryan R. Hansen and Keith B. Neeves
Summary: A microfluidic flow assay that measures the propensity to form a blood clot
Description: A deficiency in clinical hematology are techniques to diagnose a very broad range
of both deficient and excessive clotting disorders and to monitor the effects of therapeutic
interventions. The microfluidic flow assay is a method for measuring an individual’s propensity
to form a blood clot. The assay consists of a micropatterned surface that induces clot formation
and an array of microfluidic channels through which blood flows. The micropatterened surface
contains two stimuli, one for inducing platelet adhesion and another for inducing the
coagulation cascade. Most current bleeding assays test for either platelet function or
coagulation, but not both. In addition most conventional assays are conducted under static
conditions, rather than under the flow conditions of the microfluidic flow assay developed here.
Since blood is moving fluid in the body, there are several advantages to study it under flow
conditions in bleeding diagnostics.
Main Advantages of this Invention
 Tests both platelet function and
coagulation under flow
Potential Areas of Application
 Medical Devise Companies
ID number: 10004
Intel ectual Property Status:
US 8,486,349
Publication: R.R. Hansen et al. Langmuir 2011, 278, 13648-13659. (Available upon request.)
Opportunity: We are seeking an exclusive or non-exclusive licensee for marketing,
manufacturing, and sale of this technology.
For more information contact:
William Vaughan, Director of Technology Transfer
Colorado School of Mines, 1500 Illinois Street, Guggenheim Hall Suite 314, Golden, CO 80401
Phone: 303-384-2555; e-mail: wvaughan@mines.edu