Plasma based Flow Assay for Measuring
Trombin and Fibrin Generation
Abimbola Onasoga and Keith B. Neeves
Summary: A microfluidic plasma-based flow assay for measuring thrombin and fibrin
Description: Maintaining the balance between bleeding and thrombosis in patients is a
significant challenge in healthcare communities. The rate of blood flow strongly influences the
biochemical reactions that lead to coagulation. Conventional coagulation assays are conducted
under static, no flow, conditions. This invention is of a plasma-based flow assay for measuring
thrombin and fibrin generation, the two end products of the coagulation cascade. The
advantage of this test is that it integrates the coagulation cascade into a fluidic architecture,
which allows for measurement of these coagulation products under the hemodynamic
conditions found in the body. Furthermore because this is a plasma based assay (rather than
whole blood based), patient samples can be sorted for longer periods of time before being
Main Advantages of this Invention
 Measure is conducted under conditions that more closely resemble in vivo processes
 Samples can be stored for longer time periods
Potential Areas of Application
 Medical Devise Companies
 Blood monitoring
ID number: 12031
Intel ectual Property Status: US utility patent pending (application #13/929,141)
Opportunity: We are seeking an exclusive or non-exclusive licensee for marketing,
manufacturing, and sale of this technology.
For more information contact:
William Vaughan, Director of Technology Transfer
Colorado School of Mines, 1500 Illinois Street, Guggenheim Hall Suite 314, Golden, CO 80401
Phone: 303-384-2555; e-mail: