Delivery of Therapeutic Antibodies from
Biodegradable Polymer Scaffolds
Melissa D. Krebs
Summary: A direct delivery system for the administration of therapeutic antibodies
Description: Antibodies used clinically are a promising class of therapeutics. However, there are
limitations associated with their use including the need for repeated injections and the use of
large quantities due to the degradation and diffusion away from the site of interest. This
invention is an injectable antibody-laden biodegradable hydrogel that allows the antibody to
remain localized and be steadily released in a controlled manner over a sustained period of
time. The delivery system may enhance efficacy of the therapeutic agent by increasing the local
concentrations and prolonging the exposure of the treatment site. Such a method may be
especially useful for the treatment of diseases that occur in locations that are difficult to access,
such as cancers that occur in central nervous system and brain. The delivery system may also be
useful for maintaining activity of the therapeutic agent by protecting against metabolism,
degradation, and/or denaturation.
Main Advantages of this Invention:
 Controlled release of antibodies the target
 Provides a more optimal dosing regimen
 May protect activity of therapeutic agent
 Potential to reduce treatment cost
Potential Areas of Application:
 Biotechnology
 Pharmaceutical
ID number: # 13011
Release of IgG from hydrogels with varying alginate to
Chitosan ratios over the course of 7 weeks
Intel ectual Property Status: US utility application pending (#14/312,772)
Publications: N.A. Fletcher et al., Mat. Sci. Eng. C 2016, 59, 801-806. (Available upon request.)
Opportunity: Seeking a strategic partner for the development of this technology.
For more information contact:
William Vaughan, Director of Technology Transfer
Colorado School of Mines, 1500 Illinois Street, Guggenheim Hall Suite 314, Golden, CO 80401
Phone: 303-384-2555; e-mail: