Artificial Cells for Advanced Drug Delivery
Hongjun Liang
Summary: Targeted drug delivery across biological barriers using artificial cells
Description: The delivery of therapeutic and diagnostic compounds often involves crossing
biological barriers to reach target sites. The intravenous delivery of these compounds involves
conjugation or chemical bonding of the compound to a carrier molecule. This method is often
costly and/or inefficient. This invention uses hybrid artificial cells based on the latest
developments in nanotechnology for next-generation drug delivery and solves the problem of
crossing a biological barrier to deliver the drugs. The artificial cells carry therapeutic agents in
significant numbers without chemical modification of the individual drug molecules. This is
particularly advantageous for drugs that have a narrow therapeutic index and challenging
physical characteristics, such as anti-cancer drugs.
Main Advantages of this Invention
 Effective delivery of the drug through
the biological barriers
 No need to chemically alter the drug
 Administered intravenously
Potential Areas of Application
 Drug therapeutics
 Drug development
Schematic representation of the duel responsive
behavior of self-assembled nanocarriers
ID number: 9002
Intel ectual Property Status: US utility patent pending (application #12/704,416)
Publication: D. Hua et al. Macromolecules 2011, 44, 1298-1302. (Available upon request.)
Opportunity: We are seeking an exclusive or non-exclusive licensee for marketing,
manufacturing, and sale of this technology.
For more information contact:
William Vaughan, Director of Technology Transfer
Colorado School of Mines, 1500 Illinois Street, Guggenheim Hall Suite 314, Golden, CO 80401
Phone: 303-384-2555; e-mail: