Annette Bunge

RESEARCH PROJECTS

Manifestation of therapeutic or toxic effects following chemical contact with skin will only occur if there is dermal absorption. The ultimate objective of this research is to develop algorithms for predicting the rate and extent of absorption following dermal contact with a chemical. This prediction can then be used for health risk assessments or drug delivery and design. Research on this subject is conducted in collaboration with pharmaceutical chemists, toxicologists, dermatologists and computational scientists at several research facilities around the world. Funded by EPA, FDA, NIOSH, and NSF, our goals are to conduct experiments that produce well-defined and interpretable data, identify absorption mechanisms, and develop descriptive mathematical models of barrier membranes like skin.