Photo of Judith Klein-Seetharaman

Judith Klein-Seetharaman

  • CASE
  • Colorado School of Mines
    Golden, CO 80401


  • PhD, Biological Chemistry. Massachusetts Institute of Technology, Cambridge, MA (2000)
  • Diplom, Biology, Cologne University, Germany (1996)
  • Diplom, Chemistry, Cologne University, Germany (1995)


  • G protein coupled receptors; membrane proteins; protein and lipid dynamics and interactions; biosensors and biofeedback for healthy life style changes and quantified self


  • interdisciplinary research and education


  • Ye L, Maji S, Sanghera N, Gopalasingam P, Gorbunov E, Tarasov S, Epstein O, Klein-Seetharaman J. Structure and dynamics of the insulin receptor: implications for receptor activation and drug discovery. Drug Discov Today. 2017 Jul;22(7):1092-1102.
  • Kshirsagar M, Murugesan K, Carbonell JG, Klein-Seetharaman J. Multitask Matrix Completion for Learning Protein Interactions Across Diseases. J Comput Biol. 2017 Jun;24(6):501-514.
  • Insulin biosensor development: a case study. Narinder Sanghera, Alexander Anderson, Nick Nuar, Can Xie, Daniel Mitchell & Judith Klein-Seetharaman. International Journal of Parallel, Emergent and Distributed Systems Vol. 32 , Iss. 1,2017
  • Woods KN, Pfeffer J, Dutta A, Klein-Seetharaman J. Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors. Sci Rep. 2016 Nov 16;6:37290.
  • Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayr H. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017 Jan;13(1):81-90.
  • Planas-Iglesias J, Dwarakanath H, Mohammadyani D, Yanamala N, Kagan VE, Klein-Seetharaman J. Cardiolipin Interactions with Proteins. Biophys J. 2015 Sep 15;109(6):1282-94.
  • Balem F, Yanamala N, Klein-Seetharaman J. (2009) Additive effects of chlorin e6 and metal ion binding on the thermal stability of rhodopsin in vitro. Photochem Photobiol. 2009 Mar-Apr;85(2):471-8.
  • Yanamala N, Tirupula KC, Klein-Seetharaman J. (2008) Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors. BMC Bioinformatics. 2008;9 Suppl 1:S16.
  • Klein-Seetharaman J, Oikawa M, Grimshaw SB, Wirmer J, Duchardt E, Ueda T, Imoto T, Smith LJ, Dobson CM, Schwalbe H. (2002) Long-range interactions within a nonnative protein. Science. 2002 Mar 1;295(5560):1719-22.
  • Klein-Seetharaman J, Getmanova EV, Loewen MC, Reeves PJ, Khorana HG. (1999) NMR spectroscopy in studies of light-induced structural changes in mammalian rhodopsin: applicability of solution (19)F NMR. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13744-9.